Aspartato aminotransferase

aspartato aminotransferase

What is aspartate aminotransferase (AST)?

Aspartate aminotransferase (AST) is a transaminase enzyme that catalyzes the conversion of aspartate and alpha-ketoglutarate to oxaloacetate and glutamate. The AST enzyme was formerly known as serum glutamate oxalate transaminase (SGOT) and is present in all tissues except bone, with highest levels in liver and skeletal muscle.

Is aspartate aminotransferase a biomarker for liver injury?

Aspartate aminotransferase (AST), which functions to transaminate aspartate, has been commonly used as a biomarker for hepatic injury. AST is considered a less specific marker for liver injury than ALT, due to expression from other tissues, such as brain, myocardial cells and skeletal muscle cells (Yang, 2014).

What chemical reaction does aspartate aminotransferase accelerate?

At a micro level, the direct chemical reaction that aspartate aminotransferase accelerates is the conversion of an amino acid (aspartate) and acid (alpha-ketoglutarate) to a different acid ( oxaloacetate) and amino acid (glutamate).

Which aminotransferase is involved in hepatocellular injury?

Aminotransferases. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are frequently used as markers of hepatocellular injury. AST is expressed in mitochondria of the liver and cytosol of red blood cells and muscles; thus it is not specific for liver injury.

What is an aspartate aminotransferase (AST) test?

What Is an Aspartate Aminotransferase (AST) Test? The aspartate aminotransferase (AST) test is a blood test that checks for liver damage. Your doctor might order this test to find out if you have liver disease and to monitor your treatment. Your liver is an organ that has many important jobs.

What is aspartate aminotransferase used for?

Aspartate aminotransferase is an enzyme involved in the balance of proteins (amino acids). Levels of this molecule in the body can be used as a sign of liver disease and other health problems. People go to their doctor to get their AST tested as part of a standard panel.

What is AST in the blood?

AST is an enzyme your liver makes. Other organs, like your heart, kidneys, brain, and muscles, also make smaller amounts. AST is also called SGOT (serum glutamic-oxaloacetic transaminase). Normally, AST levels in your blood are low. When your liver is damaged, it puts more AST into your blood,...

What is the difference between Alt and AST liver enzymes?

Its often ordered with a test for alanine aminotransferase (ALT), another liver enzyme. ALT is more accurate than AST at detecting liver disease. It can more accurately show whether the problem is in your liver or in another part of your body, like your heart or muscles.

What chemical reaction does aspartate aminotransferase accelerate?

At a micro level, the direct chemical reaction that aspartate aminotransferase accelerates is the conversion of an amino acid (aspartate) and acid (alpha-ketoglutarate) to a different acid ( oxaloacetate) and amino acid (glutamate).

What is aspartate aminotransferase (AST)?

Aspartate aminotransferase (AST) is a transaminase enzyme that catalyzes the conversion of aspartate and alpha-ketoglutarate to oxaloacetate and glutamate. The AST enzyme was formerly known as serum glutamate oxalate transaminase (SGOT) and is present in all tissues except bone, with highest levels in liver and skeletal muscle.

What does aspartate transaminase catalyze?

Aspartate transaminase catalyzes the interconversion of aspartate and α-ketoglutarate to oxaloacetate and glutamate . L-Aspartate (Asp) + α-ketoglutarate ↔ oxaloacetate + L-glutamate (Glu)

What can cause the level of aspartate aminotransferase to be too high?

WHAT CAN CAUSE THE LEVEL OF ASPARTATE AMINOTRANSFERASE TO BE TOO HIGH? testing is done to determine the exact cause. When an organ or body tissue is injured, increased levels of AST are released into the blood. The greater the degree of tissue damage, the greater the degree of AST that is released.

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